treponema denticola treatment

 
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McDowell JV, Frederick J, Stamm L, Marconi RT. Analysis of the evidence following Koch's and Hill's criteriaHuman serum antibodies recognize Treponema denticola Msp and PrtP protease complex proteinsHuman serum antibodies (immunoglobulin G class) recognized multiple protein bands in T. denticola strains. T. denticola dwells in a complex and diverse microbial community within the oral cavity and is highly specialized to survive in this environment. However, the molecular mechanisms by which T. denticola impacts periodontal inflammation and alveolar bone resorption remain unclearBiological pathways significantly impacted by T. denticola infection in calvarial bone and calvarial tissue included leukocyte transendothelial migration, cell adhesion (immune system) molecules, cell cycle, extracellular matrix-receptor interaction, focal adhesion, B-cell receptor signaling and transforming growth factor-beta signaling pathways resulting in proinflammatory, chemotactic effects, and T-cell stimulation.New insights into the emerging role of oral spirochaetes in periodontal diseaseThis review focuses on emerging knowledge of virulence mechanisms of Treponema denticola as well as mechanisms of other less-studied oral treponemesVirulence factors of the oral spirochete Treponema denticola.There are interesting parallels with other chronic diseases caused by treponemes that may indicate similar virulence characteristics.Recent advances, especially in molecular-based methodologies, have greatly improved our knowledge of this bacterium and its role in disease.Synergistic virulence of Porphyromonas gingivalis and Treponema denticola in a murine periodontitis model.These data show that P. gingivalis and T. denticola act synergistically to stimulate the host immune response and to induce alveolar bone loss in a murine experimental periodontitis model.Polymicrobial periodontal pathogen transcriptomes in calvarial bone and soft tissue.Porphyromonas gingivalis, Treponema denticola, and Tannerella forsythia are consistently associated with adult periodontitis.Biological pathways significantly impacted by the polymicrobial infection in calvarial bone included leukocyte transendothelial migration (LTM), cell adhesion molecules, adherens junction, major histocompatibility complex antigen, extracellular matrix-receptor interaction, and antigen processing and presentation resulting in inflammatory/cytokine/chemokine transcripts stimulation in bone and soft tissue.Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomesComparisons with previously sequenced spirochete genomes revealed specific factors contributing to differences and similarities in spirochete physiology as well as pathogenic potential.Comparative analysis with previously sequenced spirochetes (T. pallidum, Borrelia burgdorferi, and Leptospira interrogans) (4–6) yielded insights into the basis for differences in their lifestyle and disease manifestations. aimed at identifying which bacterial microbes play an integral role in the onset of periodontal disease. 1992. It was found that those with periodontitis exhibited more bacteria per cell than the controls. Compared to other spirochetes, T. denticola is relatively easy to cultivate and manipulate genetically, making this an excellent model for spirochete research. 1999. 2007. Treponema denticola, Treponema vincentii, and Treponema scaliodontum require cocarboxylase in serum. 179, No. Vol. Having also come across a few of the following article abstracts, I think it's important to point out that ongoing research into T. denticola has increased our knowledge about this seemingly "benign" spirochete in recent years.Infect Immun. 67, No. 2011 Aug;26(4):229-40. doi: 10.1111/j.2041-1014.2011.00612.x. Name and History. Rekha Seshadri, Garry S. A. Myers, Hervé Tettelin, Jonathan A. Eisen, John F. Heidelberg, Robert J. Dodson, Tanja M. Davidsen, Robert T. DeBoy, Derrick E. Fouts, Dan H. Haft, Jeremy Selengut, Qinghu Ren, Lauren M. Brinkac, Ramana Madupu, Jamie Kolonay, Scott A. Durkin, Sean C. Daugherty, Jyoti Shetty, Alla Shvartsbeyn, Elizabeth Gebregeorgis, Keita Geer, Getahun Tsegaye, Joel Malek, Bola Ayodeji, Sofiya Shatsman, Michael P. McLeod, David Šmajs, Jerrilyn K. Howell, Sangita Pal, Anita Amin, Pankaj Vashisth, Thomas Z. McNeill, Qin Xiang, Erica Sodergren, Ernesto Baca, George M. Weinstock, Steven J. Norris, Claire M. Fraser, and Ian T. Paulsen. "Identification of intracellular oral species within human crevicular epithelial cells from subjects with chronic periodontitis by fluorescence in situ hybridization." 75, No. [Epub ahead of print]Just occurred to me, the 41 kd protein on the blot comes from Bb. Regular cleaning, including both the teeth and subgingival area, can remove buildups of plaque and biofilm to dislodge Treponema denticola.Patients with severe oral disease may need more extensive cleaning and scaling to successfully restore the surface of the teeth.

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