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subarachnoid hemorrhage guidelines 2019

 
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(Revised recommendation from previous guidelines), Prophylactic hypervolemia or balloon angioplasty before the development of angiographic spasm is not recommended (Class III; Level of Evidence B). The weight of evidence or opinion is in favor of the procedure or treatment. Connolly ES Jr ,et al. Neither aminocaproic acid nor tranexamic acid is approved by the US Food and Drug Administration for prevention of aneurysm rebleeding. In the most … For patients with ruptured aneurysms judged to be technically amenable to both endovascular coiling and neurosurgical clipping, endovascular coiling should be considered. 6. When the blood is located in the sulci, CTA should be scrutinized for vasculitis, and DSA is recommended for confirmation.109 Others have shown that CTA may not reveal small aneurysms and that 2- and 3-dimensional cerebral angiography should be performed, especially when the hemorrhage is accompanied by loss of consciousness.110 In cases of diffuse aSAH pattern, most agree that negative CTA should be followed by 2- and 3-dimensional cerebral angiography. 11. Contact Us, A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association, and on behalf of the American Heart Association Stroke Council, Council on Cardiovascular Radiology and Intervention, Council on Cardiovascular Nursing, Council on Cardiovascular Surgery and Anesthesia, and Council on Clinical Cardiology. Acute diagnostic workup should include noncontrast head CT, which, if nondiagnostic, should be followed by lumbar puncture (Class I; Level of Evidence B). Anemia is common after aSAH and may compromise brain oxygen delivery.326 Transfusion of red blood cells in anemic patients with aSAH results in a significant rise in cerebral oxygen delivery and a reduction in oxygen extraction ratio.327 Data obtained from prospective registries of patients with aSAH suggest that higher hemoglobin values are associated with improved outcomes after aSAH.328,329 Nevertheless, thresholds for blood transfusion have been dictated in a nonsystematic manner and have therefore varied widely. Aggressive control of fever to a target of normothermia by use of standard or advanced temperature modulating systems is reasonable in the acute phase of aSAH. Many significant advances in the understanding of aSAH-induced vasospasm and DCI have been made since publication of the previous version of these guidelines, which focused on prevention with oral nimodipine and maintenance of euvolemia, as well as treatment with triple-H therapy (hemodynamic augmentation therapy) and/or endovascular therapy with vasodilators and angioplasty balloons. 1. Between the time of aSAH symptom onset and aneurysm obliteration, blood pressure should be controlled with a titratable agent to balance the risk of stroke, hypertension-related rebleeding, and maintenance of cerebral perfusion pressure. The use of fludrocortisone acetate and hypertonic saline solution is reasonable for preventing and correcting hyponatremia (Class IIa; Level of Evidence B). Guidelines for the management of aneurysmal subarachnoid hemorrhage: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Definition of Classes and Levels of Evidence Used in AHA Stroke Council Recommendations. The use of packed red blood cell transfusion to treat anemia might be reasonable in patients with aSAH who are at risk of cerebral ischemia. Predicting the growth of an individual intracranial aneurysm and its potential for rupture in a given patient remains problematic. In 1 large single-institution study in which anticonvulsants were used routinely, adverse drug effects were seen in 23% of patients.276 Another single-center retrospective study found that the use of prophylactic phenytoin was independently associated with a worse cognitive outcome at 3 months after aSAH.291 Data pooled from trials of the impact of other therapies also suggest a worse outcome in those treated with anticonvulsants, but use of anticonvulsants was also associated with vasospasm, DCI, and fever, which suggests that there may have been bias in who was treated with antiepileptic drugs.292 Although retrospective studies have not demonstrated a benefit for use of prophylactic anticonvulsants after aSAH,273,288 the studies were small and hampered by limitations (eg, anticonvulsant levels were not routinely monitored).2,273,288. Heparin-induced thrombocytopenia and deep venous thrombosis are relatively frequent complications after aSAH. Perfusion imaging with CT or magnetic resonance can be useful to identify regions of potential brain ischemia. Although randomized trials are unavailable, there may be a very clear clinical consensus that a particular test or therapy is useful or effective. Treatment of high blood pressure with antihypertensive medication is recommended to prevent ischemic stroke, intracerebral hemorrhage, and cardiac, renal, and other end-organ injury (Class I; Level of Evidence A). The only multicenter randomized trial comparing microsurgical and endovascular repair, ISAT, randomized 2143 of 9559 screened patients with aSAH across 42 neurosurgical centers.140 For a patient to be considered eligible for the trial, neurosurgeons and interventionalists had to agree that the aneurysm was comparably suitable for treatment with either modality. The resulting draft was sent to the entire writing group for comment. A nonrandomized study not included in the meta-analysis compared 95 patients who underwent aneurysm clipping, cisternal blood evacuation, and lamina terminalis fenestration with 28 comparable, non–blood-cleansed, endovascular therapy–treated patients and found that shunt-dependent hydrocephalus occurred in 17% of surgical patients versus 33% of patients treated with endovascular therapy (statistical significance not reported).237, aSAH-associated acute symptomatic hydrocephalus should be managed by cerebrospinal fluid diversion (EVD or lumbar drainage, depending on the clinical scenario) (Class I; Level of Evidence B). Temporary clipping is frequently used to improve surgical conditions and prevent intraoperative rupture during the surgical dissection of aneurysms. 20. Endovascular procedures differ from open procedures in that anticoagulation with heparin is frequently administered during the embolization of aneurysms. 7. Despite the classic presentation of aSAH, individual findings occur inconsistently, and because the type of headache from aSAH is sufficiently variable, misdiagnosis or delayed diagnosis is common. Stroke. Local Info The objective of this study was to investigate the independent risk factors affecting clinical outcomes in intracranial aneurysm patients with poor-grade aneurysm subarachnoid hemorrhage (aSAH) underwent different intervention … (New recommendation), Magnetic resonance imaging (fluid-attenuated inversion recovery, proton density, diffusion-weighted imaging, and gradient echo sequences) may be reasonable for the diagnosis of aSAH in patients with a nondiagnostic CT scan, although a negative result does not obviate the need for cerebrospinal fluid analysis (Class IIb; Level of Evidence C). 6. Determination of aneurysm treatment, as judged by both experienced cerebrovascular surgeons and endovascular specialists, should be a multidisciplinary decision based on characteristics of the patient and the aneurysm. Various diagnostic tools are commonly used to identify (1) arterial narrowing and/or (2) perfusion abnormalities or reduced brain oxygenation. Although CTA is sometimes considered sufficient on its own when an aneurysm will be treated with surgical clipping,114 substantial controversy remains about the ability of CTA to determine whether or not an aneurysm is amenable to endovascular therapy.115–120 In 1 series,115 95.7% of patients with aSAH were referred for treatment on the basis of CTA. Such use led to a decreased incidence in rebleeding without increasing the risk of DCI, but 3-month clinical outcomes were not affected.138 There was an increased risk of deep venous thrombosis but not pulmonary embolism. Some studies have reported no impact on outcome,276,278 whereas others found seizures to be independently associated with worse outcome.275 Two recent large, retrospective, single-institution studies of patients with aSAH found that nonconvulsive status epilepticus is a very strong predictor of a poor outcome.285,286 Although high-quality evidence for routine anticonvulsant use in aSAH is lacking, short-term prophylactic antiepileptic therapy is still commonly used in patients with aSAH,274,276,278 based on the argument that seizures in acutely ill patients with aSAH could lead to additional injury or rebleeding from an unsecured aneurysm. First, the case for nimodipine is even stronger, with a recent comprehensive meta-analysis confirming improved neurological outcomes by preventing processes other than large-vessel narrowing.209,210 Although there have been sparse new important data on the lack of benefit for prophylactic hypervolemia compared with maintenance of euvolemia, new data show that both prophylactic angioplasty of the basal cerebral arteries and antiplatelet prophylaxis are ineffective in reducing morbidity.211–213 Similarly, the only supportive data for the use of lumbar drainage come from a single case-control study,214 although there is ongoing investigation on the value of this intervention to reduce arterial spasm and DCI.214, The data are a bit better for intrathecal thrombolytic infusions, with a recent meta-analysis of 5 randomized, controlled trials suggesting a benefit despite some methodological weaknesses.215,216 There are also emerging data for several novel methods to reduce the incidence and ischemic consequences of aSAH-induced vasospasm. Stroke. A variety of titratable medications are available. The rationale for comprehensive stroke centers is based on the success of similar models for trauma. Prevention of intraoperative hyperglycemia during aneurysm surgery is probably indicated (Class IIa; Level of Evidence B). aSAH indicates aneurysmal subarachnoid hemorrhage; CTA, computed tomography angiography; DSA, digital subtraction angiography; CT, computed tomography; DSA, digital subtraction angiography; EVD, external ventricular drainage; DCI, delayed cerebral ischemia; and WFNS, World Federation of Neurological Surgeons. Endorsed by the American Association of Neurological Surgeons and Congress of Neurological Surgeons; and by the Society of NeuroInterventional Surgery. Definition of Classes and Levels of Evidence Used in AHA Stroke Council Recommendations. In an epidemiological study of Finnish smokers who were monitored for >13 years, increased consumption of yogurt (but not all dairy products) was associated with a higher risk of aSAH.41 Greater vegetable consumption is associated with a lower risk of stroke and aSAH.42 Higher coffee and tea consumption43 and higher magnesium consumption44 were associated with reduced risk of stroke overall but did not change the risk of aSAH. (It should be noted that this agent has been shown to improve neurological outcomes but not cerebral vasospasm. In some patients, increased mean arterial pressures may increase cerebral blood flow in the setting of autoregulatory dysfunction. Therefore, urgent evaluation and treatment of patients with suspected aSAH is recommended. One of the main goals of the anesthetic technique is keeping the patient motionless to optimize the quality of the images used to perform the endovascular procedure; hence, general anesthesia with endotracheal intubation is often preferred for these procedures. Surgical clipping or endovascular coiling of the ruptured aneurysm should be performed as early as feasible in the majority of patients to reduce the rate of rebleeding after aSAH (Class I; Level of Evidence B). Systemic hypothermia has been used in several clinical settings, including head injury, ischemic stroke, and circulatory arrest, to protect the brain against ischemic injury.182–188 Use of hypothermia during craniotomy for the treatment of ruptured cerebral aneurysm was evaluated in a multicenter randomized, controlled trial. Clazosentan, an endothelin-1 receptor antagonist, had been shown to be associated with a dose-dependent reduction in the incidence of angiographic vasospasm in a phase IIb trial (Clazosentan to Overcome Neurological iSChemia and Infarct OccUrring after Subarachnoid hemorrhage [CONSCIOUS-1]).220 A benefit for clinical outcomes was not initially apparent but then was judged present when a stricter definition of vasospasm-related stroke was used. Although there is some suggestion of reduction in delayed ischemic deficits associated with magnesium infusion, a benefit has not been conclusively shown in a meta-analysis.222 A phase 3 trial (Intravenous Magnesium sulfate for Aneurysmal Subarachnoid Hemorrhage [IMASH]) did not support any clinical benefit from magnesium infusion over placebo in aSAH.223 A larger randomized trial is under way. DSA with 3-dimensional rotational angiography is indicated for detection of aneurysm in patients with aSAH (except when the aneurysm was previously diagnosed by a noninvasive angiogram) and for planning treatment (to determine whether an aneurysm is amenable to coiling or to expedite microsurgery). 8. However, a subsequent trial (CONSCIOUS-2) that tested the drug in patients treated with aneurysm clipping found no improvement in clinical outcome in the clazosentan group.221 A similar study in patients treated with coiling (CONSCIOUS-3) was then stopped before completion. A warning or sentinel headache that precedes the aSAH-associated ictus is also reported by 10% to 43% of patients.83,84 This sentinel headache increases the odds of early rebleeding 10-fold.85 Most intracranial aneurysms remain asymptomatic until they rupture. This review does not discuss the multitude of ongoing studies. Blacks and Hispanics have a higher incidence of aSAH than white Americans.6,24,25, Behavioral risk factors for aSAH include hypertension, smoking, alcohol abuse, and the use of sympathomimetic drugs (eg, cocaine). In 4.4% of patients, CTA did not provide enough information to determine the best treatment, and those patients required DSA; 61.4% of patients were referred to endovascular treatment on the basis of CTA; and successful coiling was achieved in 92.6%. In case of intraprocedural rupture, rapid reversal of antiplatelet activity can be attempted by platelet transfusion. A retrospective analysis of 220 patients with subarachnoid haemorrhage, Minor leak before rupture of an intracranial aneurysm and subarachnoid hemorrhage of unknown etiology, The minor leak preceding subarachnoid hemorrhage, Importance of the recognition of a warning leak as a sign of a ruptured intracranial aneurysm, Hypertens as a risk factor for epilepsy after aneurysmal subarachnoid hemorrhage and surgery, Seizures associated with spontaneous subarachnoid hemorrhage, Determining the sensitivity of computed tomography scanning in early detection of subarachnoid hemorrhage, MRI in acute subarachnoid haemorrhage: findings with a standardised stroke protocol, Problems with diagnosis by fluid-attenuated inversion recovery magnetic resonance imaging in patients with acute aneurysmal subarachnoid hemorrhage, Diagnostic value of magnetic resonance imaging in perimesencephalic and nonperimesencephalic subarachnoid hemorrhage of unknown origin, Comparison of 16-row multislice CT angiography with conventional angiography for detection and evaluation of intracranial aneurysms, Detection of aneurysms by 64-section multidetector CT angiography in patients acutely suspected of having an intracranial aneurysm and comparison with digital subtraction and 3D rotational angiography. Determination of aneurysm treatment, as judged by both experienced cerebrovascular surgeons and endovascular specialists, should be a multidisciplinary decision based on characteristics of the patient and the aneurysm. The aim of this guideline is to present current and comprehensive recommendations for the diagnosis and treatment of aneurysmal subarachnoid hemorrhage (aSAH). 1. (Revised recommendation from previous guidelines), Prophylactic hypervolemia or balloon angioplasty before the development of angiographic spasm is not recommended (Class III; Level of Evidence B). This is an important consideration because the observed decrease in case fatality is related to improvements in survival among hospitalized patients with aSAH. 5. This imaging test can detect bleeding in your brain.Your doctor may inject a contrast dye to view your blood vessels in greater detail (CT angiogram). Aggressive control of fever to a target of normothermia by use of standard or advanced temperature modulating systems is reasonable in the acute phase of aSAH (Class IIa; Level of Evidence B). This statement was approved by the American Heart Association Science Advisory and Coordinating Committee on January 30, 2012. The prior aneurysmal subarachnoid hemorrhage (aSAH) guidelines, sponsored by the AHA Stroke Council, were previously issued in 19941 and 2009.2 The 2009 guidelines covered literature through November 1, 2006.2 The present guidelines primarily cover literature published between November 1, 2006, and May 1, 2010, but the writing group has strived to place these data in the greater context of the prior publications and recommendations. 1-800-AHA-USA-1 (New recommendation), Aneurysm rebleeding is associated with very high mortality and poor prognosis for functional recovery in survivors. Complete obliteration of the aneurysm is recommended whenever possible (Class I; Level of Evidence B). Maintenance of euvolemia and normal circulating blood volume is recommended to prevent DCI. In addition to the size and location of the aneurysm and the patient's age and health status, it might be reasonable to consider morphological and hemodynamic characteristics of the aneurysm when discussing the risk of aneurysm rupture (Class IIb; Level of Evidence B). 2012; 43: 1711-1737. Global cerebral edema after subarachnoid hemorrhage: frequency, predictors, and impact on outcome, Prognostic factors for outcome in patients with aneurysmal subarachnoid hemorrhage, Patterns of cerebral infarction in aneurysmal subarachnoid hemorrhage, Impact of medical complications on outcome after subarachnoid hemorrhage, Medical complications of aneurysmal subarachnoid hemorrhage: a report of the Multicenter, Cooperative Aneurysm Study: participants of the Multicenter Cooperative Aneurysm Study, Ruptured intracranial aneurysms: factors affecting the rate and outcome of endovascular treatment complications in a series of 782 patients (CLARITY study), Impact of hospital-related factors on outcome after treatment of cerebral aneurysms, Mortality rates after subarachnoid hemorrhage: variations according to hospital case volume in 18 states, Effect of endovascular services and hospital volume on cerebral aneurysm treatment outcomes, Warning signs in subarachnoid hemorrhage: a cooperative study, Sentinel headaches in aneurysmal subarachnoid haemorrhage: what is the true incidence? Endovascular coiling may receive increased consideration in the elderly (>70 y of age), in those presenting with poor-grade WFNS classification (IV/V) aSAH, and in those with aneurysms of the basilar apex. The value of other calcium antagonists, whether administered orally or intravenously, remains uncertain. Induced hypothermia during aneurysm surgery is not routinely recommended but may be a reasonable option in selected cases (Class III; Level of Evidence B). Monitoring volume status in certain patients with recent aSAH by some combination of central venous pressure, pulmonary wedge pressure, and fluid balance is reasonable, as is treatment of volume contraction with crystalloid or colloid fluids (Class IIa; Level of Evidence B). Table 1. With the increasing use of intravascular stents, the administration of antiplatelet agents (aspirin, clopidogrel, and glycoprotein IIb/IIIa receptor antagonists) during these procedures has become more common. Microsurgical clipping may receive increased consideration in patients presenting with large (>50 mL) intraparenchymal hematomas and middle cerebral artery aneurysms. 13. Two additional medical complications are heparin-induced thrombocytopenia333–335 and deep venous thrombosis. Each subcategory was led by 1 author, with 1 or 2 additional coauthors who made contributions. When followed up on magnetic resonance imaging, larger aneurysms (≥8 mm in diameter) tended to grow more over time,45 which implies a higher risk of rupture. Instructions for obtaining permission are located at http://www.heart.org/HEARTORG/General/Copyright-Permission-Guidelines_UCM_300404_Article.jsp. To purchase additional reprints, call 843-216-2533 or e-mail kelle. In selected patients with giant aneurysms, deep hypothermia with circulatory arrest under cardiopulmonary extracorporeal circulation has been shown to be a feasible and possibly useful technique, but outcome data are lacking.192–196 Transient cardiac pause induced by adenosine has been used to control bleeding from intraoperative aneurysm rupture or to decompress large aneurysms and facilitate aneurysm clip application197,198; however, controlled studies are needed to validate this intervention. 4. Low-volume hospitals (eg, <10 aSAH cases per year) should consider early transfer of patients with aSAH to high-volume centers (eg, >35 aSAH cases per year) with experienced cerebrovascular surgeons, endovascular specialists, and multidisciplinary neuro-intensive care services. 8. aSAH indicates aneurysmal subarachnoid hemorrhage; CTA, computed tomography angiography; DSA, digital subtraction angiography; CT, computed tomography; DSA, digital subtraction angiography; EVD, external ventricular drainage; DCI, delayed cerebral ischemia; and WFNS, World Federation of Neurological Surgeons. A high level of suspicion for aSAH should exist in patients with acute onset of severe headache (Class I; Level of Evidence B). If an aneurysm is detected by CTA, this study may help guide the decision for the type of aneurysm repair, but if CTA is inconclusive, DSA is still recommended (except possibly in the instance of classic perimesencephalic SAH). The use of packed red blood cell transfusion to treat anemia might be reasonable in patients with aSAH who are at risk of cerebral ischemia. DSA with 3-dimensional rotational angiography is indicated for detection of aneurysm in patients with aSAH (except when the aneurysm was previously diagnosed by a noninvasive angiogram) and for planning treatment (to determine whether an aneurysm is amenable to coiling or to expedite microsurgery). 2012;43:1711–1737. Customer Service There are insufficient data on pharmacological strategies and induced hypertension during temporary vessel occlusion to make specific recommendations, but there are instances when their use may be considered reasonable (Class IIb; Level of Evidence C). There is little information in the literature about anesthetic management of patients undergoing endovascular treatment of ruptured cerebral aneurysms.199–201 Generally, the anesthetic principles that apply to open surgical treatment of ruptured cerebral aneurysms also apply to endovascular treatment. 10. Acute hydrocephalus associated with aSAH is usually managed by external ventricular drainage (EVD) or lumbar drainage. Inter- and intraobserver agreement in CT characterization of nonaneurysmal perimesencephalic subarachnoid hemorrhage. Nicardipine may give smoother blood pressure control than labetalol135 and sodium nitroprusside,136 although data showing different clinical outcomes are lacking. Many of these can be found at http://www.strokecenter.org/trials/. Washington University School of Medicine (St. Louis), University of California at San Francisco Medical Center, Micrus Endovascular, >1 y ago, served as DSMB Chair. Weaning EVD over >24 hours does not appear to be effective in reducing the need for ventricular shunting. doi: 10.1056/nejmcp1605827 . Many of these can be found at http://www.strokecenter.org/trials/. Experts in each field were screened for important conflicts of interest and then met by telephone to determine subcategories to evaluate. Between the time of aSAH symptom onset and aneurysm obliteration, blood pressure should be controlled with a titratable agent to balance the risk of stroke, hypertension-related rebleeding, and maintenance of cerebral perfusion pressure. In a retrospective study of 109 patients with proven aSAH, headache was present in 74%, nausea or vomiting in 77%, loss of consciousness in 53%, and nuchal rigidity in 35%.88 As many as 12% of patients die before receiving medical attention. Subarachnoid Hemorrhage Complications. "Guidelines for the management of aneurysmal subarachnoid hemorrhage a guideline for healthcare professionals from the American heart association/American stroke association." This table represents the relationships of writing group members that may be perceived as actual or reasonably perceived conflicts of interest as reported on the Disclosure Questionnaire, which all writing group members are required to complete and submit. Hospital Characteristics and Systems of Care Although the case fatality of aSAH remains high worldwide,5 mortality rates from aSAH appear to have declined in industrialized nations over the past 25 years.9,11,15,58,59 One study in the United States reported a decrease of ≈1% per year from 1979 to 1994.60 Others have shown that case fatality rates decreased from 57% in the mid-1970s to 42% in the mid-1980s,11 whereas rates from the mid-1980s to 2002 are reported to be anywhere from 26% to 36%.6,12,13,18,20,61,62 Mortality rates vary widely across published epidemiological studies, ranging from 8% to 67%.59 Regional variations become apparent when numbers from different studies are compared.

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